空间计量经济学（SpatialEconometrics)术语首先是Anselin提出来的。（)

3．药物代谢动力学(pharmacokinetics)

药物代谢动力学(pharmacokinetics)

请解释术语：Biopharmaceutics、Pharmacokinetics、表观分布容积、稳态血药浓度、非线性药物动力学、二室模型、生物利用度。

Proxemics(空间关系学) is the study of what governs how closely one person stands to another. People who feel close will be close, though the actual distances will vary between cultures. For Amreicans we can discern four main categories of distance: intimate, personal, social and public. Intimate ranges from direct contact to about 45 centimeters. This is for the closest relationships such as those between husband and wife. Beyond this comes personal distance. This stands at between 45 and 80 centimeters. It is the most usual distance maintained for conversations between friends and relatives. Social distance covers people who work together or are meeting at social gatherings. Distances here tend to be kept between 1.30 to 2 meters. Beyond this comes public distance, such as that between a lecturer and his audience. All cultures draw lines between what is an appropriate and what is an inappropriate social distance for different types of relationship. They differ, however, in where they draw these lines. Look at an international reception withrepresentatives from the US and Arabic countries conversing and you will see the Americans pirouetting(快速旋转) backwards around the hall pursued by their Arab partners. The Americans will be trying to keep the distance between themselves and their partners which they have grown used to regarding as “normal”. They probably will not even notice themselves trying to adjust the distance between themselves and their partners, though they may have vague feeling that their Arab neighbors are being a bit “pushy”. The Arab, on the other hand, coming from a culture where much closer distance is the norm, may be feeling that the Americans are being “stand-offish”. Finding themselves happier standing close to and even touching those they are in conversation with they will persistently pursue the Americans round the room trying to close the distance between them. The appropriateness of physical contact varies between different cultures too. One study of the number of times people conversing in coffee shops over a one hour period showed the following interesting variations: London, 0; Florida, 2; Paris, 10; and Puerto Rico 180. Not only dose it vary between societies, however, it also varies between different subcultures within one society. Young people in Britain, for example, are more likely to touch and hug friends than are the older generation. This may be partly a matter of growing older, but it also reflects the fact that the older generation grew up at a time when touching was less common for all age groups. Forty years ago, for example, footballers would never hug and kiss one another on the field after a goal as they do today. In proxemics, ____ governs the standing space between two persons.

A.distance

B.culture

C.conversation

D.relationship

Sleep Problems Plague the Older Set

Older Americans often have difficulty getting a good night's rest. It's a huge quality-of-life problem, experts say, because contrary to popular belief, seniors require about the same amount of sleep as younger adults.

"Sleep problems and sleep disorders are not an inherent (固有的) part of aging," said Dr. Harrison G. Bloom, an associate clinical professor of geriatrics (老年病学) and medicine at the Mount Sinai School of Medicine in New York City. "It's pretty much of a myth that older people need less sleep than younger people."

Yet, in a study published recently in The American Journal of Medicine, researchers found that more than half of older Americans have problems getting the sleep they need.

Older people tend to have "sleep fragmentation," meaning they wake up more often during the night, said study author Dr. Julie Gammack, an assistant professor of medicine in the Division of Geriatric Medicine at St. Louis University.

They also seem to get less "REM" sleep, the type of sleep during which rapid eye movement occurs, Bloom added.

It's unclear what role these naturally occurring changes in sleep patterns have on a person's quality of life, Bloom said "What is important, though, is that older people often have actual sleep disorders and problems with sleep," he said.

And, experts say, there is usually more than one cause.

"Sleep trouble in older adults is typically associated with acute and chronic illnesses, including specific sleep disorders like sleep apnea (呼吸暂停) and restless leg syndrome that appear with greater frequency in older populations," said Michael V. Vitiello, a professor of psychiatry and behavioral sciences and associate director of the University of Washington's Northwest Geriatric Education Center.

Taking multiple medications, as many older people do, can also lead to fatigue and "hypersomnia," or being tired all the time, Bloom added.

Another big problem, he noted, is depression and anxiety. "Those are very commonly associated with sleep problems."

Despite the prevalence (流行) of sleep difficulties in older adults, many patients aren't getting the help they need As a result, problems like insomnia (失眠), restless leg syndrome and sleep apnea are underdiagnosed and undertreated, Bloom said.

Sleep problems can seriously affect one's quality of life.

A．Right

B．Wrong

C．Not mentioned

根据下列材料请回答 16～22 题：

Sleep Problems Plague the Older Set

Older Americans often have difficulty getting a good night’S rest.It's a huge quality—of-life problem，experts say，because contrary to popular belief，seniors require about the same amount of sleep as younger adults.

“Sleep problems and sleep disorders are not an inherent(固有的)pa rt of aging，”said Dr.Harrison G.Bloom，an associate clinical professor of geriatrics(老年病学)and medicine at the Mount Sinai School of Medicine in New York City.“It’S pretty much of a myth that older people need less sleep than younger people.”

Yet in a study published recently in The American Journal of Medicine，researchers found that more than half of older Americans have problems getting the sleep they need.

older people tend to have“sleep fragmentation，”meaning they wake up more often during the night，said study author Dr.Julie Gammck，an assistant professor of medicine in the Division of Geriatric Medicine at St.Louis University.

They also seem to get less“REM”sleep，the type of sleep during which rapid eye movement occurs，Bloom added.

It’s unclear what role these naturally occurring changes in sleep patterns have on person’s quality of life，Bloom said.“What is important，though，is that older people often have actual sleep disorders and problems with sleep，”he said.

And，experts say，there is usually more than one cause.

“Sleep trouble in older adults is typically associated with acute and chronic illnesses，including specific sleep disorders like sleep apnea(呼吸暂停)and restless leg syndrome that appear with greater frequency in older populations，”said Michael V.Vitiello , a professor of psychiatry and behavioral sciences and associate director of the University of Washington’S Northwest Geriatric Education Center.

Taking multiple medications，as many older people do，can also lead t0 fatigue a“ hypersomnia ，”or being tired all the time，Bloom added.

Another big problem，he noted，IS depression and anxiety.“Those are very commonly associated with sleep problems.”

Despite the prevalence(流行)of sleep difficulties in older adults，many patients Aren’t getting the help they need。As a result，problems like insomnia(失眠)，restless leg syndrome and sleep apnea are underdiagnosed and undertreated，Bloom said.

第 16 题 Sleep problems can seriously affect one’s quality of life

A．Right

B．Wrong

C．Not mentioned

Sleep Problems Plague the Older Set

Older Americans often have difficulty getting a good night's rest. It's a huge quality-of-life problem, experts say, because contrary to popular belief, seniors require about the same amount of sleep as younger adults.

"Sleep problems and sleep disorders are not an inherent (固有的) part of aging," said Dr. Harrison G. Bloom, an associate clinical professor of geriatrics (老年病学) and medicine at the Mount Sinai School of Medicine in New York City. "It's pretty much of a myth that older people need less sleep than younger people."

Yet, in a study published recently in The American Journal of Medicine, researchers found that more than half of older Americans have problems getting the sleep they need.

Older people tend to have "sleep fragmentation," meaning they wake up more often during the night, said study author Dr. Julie Gammack, an assistant professor of medicine in the Division of Geriatric Medicine at St. Louis University.

They also seem to get less "REM" sleep, the type of sleep during which rapid eye movement occurs, Bloom added.

It's unclear what role these naturally occurring changes in sleep patterns have on a person's quality of life, Bloom said "What is important, though, is that older people often have actual sleep disorders and problems with sleep," he said.

And, experts say, there is usually more than one cause.

"Sleep trouble in older adults is typically associated with acute and chronic illnesses, including specific sleep disorders like sleep apnea (呼吸暂停) and restless leg syndrome that appear with greater frequency in older populations," said Michael V. Vitiello, a professor of psychiatry and behavioral sciences and associate director of the University of Washington's Northwest Geriatric Education Center.

Taking multiple medications, as many older people do, can also lead to fatigue and "hypersomnia," or being tired all the time, Bloom added.

Another big problem, he noted, is depression and anxiety. "Those are very commonly associated with sleep problems."

Despite the prevalence (流行) of sleep difficulties in older adults, many patients aren't getting the help they need As a result, problems like insomnia (失眠), restless leg syndrome and sleep apnea are underdiagnosed and undertreated, Bloom said.

Sleep problems can seriously affect one's quality of life.

A．Right

B．Wrong

C．Not mentioned