第3题
【简答题】case study A 25-year-old Mediterranean female presents to her obstetrician at 12-weeks gestation for her first prenatal visit. This is her first pregnancy, and she is concerned about her baby and the risk of inheriting a “blood ” disease like others in her family. The patient reports a personal history of mild anemia but nothing as severe as her brother who required frequent transfusions and died at age 10. The patient was told by her physician that she did not need to take iron supplementation for her anemia. Patient deny having any anemic symptoms. Her physical exam is consistent with a 12-week pregnancy and ultrasound confirmed an intrauterine pregnancy at 12-weeks gestation. The patient’s hemoglobin level shows a hypochromic, microcytic( small sized red cell) anemia( hemoglobin, 9g/dL) and hemoglobin electrophoresis demonstrated increased hemoglobin A2 level( 4.0 percent) and increased fetal hemoglobin level, a pattern consistent with β thalassemia minor. The patient underwent chorionic villus sampling to assess whether the fetus was affected, and the diagnosis returned in several hours. What is the molecular genetics behind this disorder? What was the likely test and what is the biochemical basis?
第4题
【简答题】A 47-year-old female is brought to the emergency department with complaints of malaise, nausea and vomiting, and fatigue. The patient reveals a long history of alcohol abuse for the last 10 years requiring drinks daily especially in the morning an an “eye opener.” she has been to rehab on several occasions for alcoholism but has not been able to stop drinking. She is currently homeless and jobless. She denies cough, fever, chills, upper respiratory symptoms, sick contacts, recent travel, hematemesis, or abdominal pain. She reports feeling hungry and has not eaten very well in a long time. On physical exam she appears malnourished but in no distress. Her physical exam is normal. Her blood count reveals a normal white blood cell count but does show an anemia with large red blood cells. Her amylase, lipase, and liver function tests were normal. 1.What is the most likely cause of her anemia? 2.What is the molecular basis for the large erythrocytes?
第7题
【简答题】回答关于大肠菌群测定(GB 4789.3-2016 第一法)的有关问题:①什么是大肠菌群? ②食品中大肠菌群的测定具有什么食品卫生学意义? ③大肠菌群的国标检验法采用哪三步? ④对某两个食品检样A、B进行大肠菌群测定,根据证实为大肠菌群的阳性管数,查MPN检索表,A检样的MPN为18,B检样的MPN为9.2,若A检样选择100、10-1、10-2三个浓度,而B检样选择10-1、10-2、10-3三个浓度,则100g的A、B检样的大肠菌群最可能数(MPN)分别是多少?答: 100g A检样的大肠菌群最可能数(MPN)是 。100g B检样的大肠菌群最可能数(MPN)是 。
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